The demonstrators renewed their weekly protests against Netanyahu, demanding his resignation amid corruption charges against him and his mishandling of the COVID-19 crisis.
The protest came in the midst of the third lockdown as the occupied Palestine moves forward with a vaccination campaign.
Netanyahu's trial was scheduled to resume this week but has been postponed indefinitely due to stricter COVID-19 restrictions.
The Israeli prime minister has been charged with bribery, fraud and breach of trust in three cases.